Dosing interval for a decaying drug concentration

Dosing interval for a decaying drug concentration

IP 3
9 marks

After one dose of a medicine, the concentration in a patient’s blood is modelled by \(C=12e^{-0.2t}\) mg/L, where \(t\) is the time in hours after the dose. The medicine is effective only while \(C\ge 3\). Assume that when a second dose is taken, its concentration adds to whatever remains.

  1. Find, in the form \(k\ln m\), the longest time after one dose for which the medicine remains effective.[3]
  2. A second dose is taken \(6\) hours after the first. Show that the concentration immediately afterwards is \(12\left(1+e^{-1.2}\right)\) mg/L, and find how long after the second dose the medicine remains effective.[4]
  3. Explain why the answer to (b) is longer than the answer to (a), and state one way in which the model may be unrealistic.[2]

Solution:

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Answer:(a) \(5\ln 4\approx 6.93\) h (b) \(5\ln\left(4+4e^{-1.2}\right)\approx 8.25\) h

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